![]() ![]() ![]() Birth incidences of MPS IV, VI, and VII were 0.14, 0.04 and 0.027 per 100,000 live births. MPS I, II, and III had the highest incidence rate at birth (0.26/100,000) and prevalence rates of 0.70–0.71 per million. Prevalence was found to be 2.67 per 1 million. Incidence of MPS in the US was found to be 0.98 per 100,000 live births. We obtained information from 789 MPS patients during a 20-year period. ![]() Incidence rates were calculated for each state. The incidence and prevalence rates were calculated for each disease. US population information was obtained from the National Center for Health Statistics. Data included year of birth, patient geographic location, and MPS variant type. This retrospective study examined all diagnosed cases of MPS from 1995 to 2015 in the US using the National MPS Society database records. This study aimed to identify MPS incidence and prevalence in the US at a national and state level to guide clinicians and policy makers. Previous studies on incidence and prevalence of MPS mainly focused on countries other than the United States (US), showing considerable variation by country. Mucopolysaccharidoses (MPS) are rare, inherited lysosomal storage disorders characterized by progressive multiorgan involvement.
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